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Differential Effects of n-3 and n-6 Fatty Acids on Carotid Plaque and Its Progression: Analyses from The Multi-Ethnic Study of Atherosclerosis

By Kristen N Smith PhD RDN Mary R Dicklin PhD Kevin Maki PhD | Apr 1, 2018 | 0 Comments

Differential Effects of n-3 and n-6 Fatty Acids on Carotid Plaque and Its Progression: Analyses from The Multi-Ethnic Study of Atherosclerosis By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD, CLS, FNLA  Background: The process of atherosclerotic development is multifactorial involving inflammation, endothelial activation, oxidative stress and lipid accumulation…

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ODYSSEY Outcomes Trial: Topline Results and Clinical Implications

By Kevin Maki PhD | Mar 26, 2018 | 0 Comments

ODYSSEY Outcomes Trial: Topline Results and Clinical Implications By Kevin C Maki, PhD, CLS, FNLA; Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD  Background: Cardiovascular disease (CVD) event risk is high in those with recent acute coronary syndromes (ACS), despite treatment with evidence-based preventive therapies. Prior research has shown that CVD event risk…

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24-Hour Urinary Collection Data Support Strong Associations between Sodium and Potassium Excretion and Blood Pressure in the National Health and Nutrition Examination Survey

By Kristen N Smith PhD RDN Mary R Dicklin PhD Kevin Maki PhD | Mar 5, 2018 | 0 Comments

24-Hour Urinary Collection Data Support Strong Associations between Sodium and Potassium Excretion and Blood Pressure in the National Health and Nutrition Examination Survey By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: It is well established that hypertension is an important modifiable risk factor for cardiovascular disease (CVD),…

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Summary of Results from a Trial of a Novel Selective PPARɑ Modulator, Pemafibrate, on Lipid and Glucose Metabolism in Patients with Type 2 Diabetes and Hypertriglyceridemia1

By Kristen N Smith PhD RDN Mary R Dicklin PhD Kevin Maki PhD | Mar 5, 2018 | 0 Comments

Summary of Results from a Trial of a Novel Selective PPARɑ Modulator, Pemafibrate, on Lipid and Glucose Metabolism in Patients with Type 2 Diabetes and Hypertriglyceridemia By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death in persons with…

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Substituting a Type-4 Resistant Starch for Available Carbohydrate Reduces Postprandial Glucose, Insulin and Hunger: An Acute, Randomized, Double-Blind, Controlled Study

By Kristen N Smith PhD RDN Mary R Dicklin PhD Kevin Maki PhD | Feb 15, 2018 | 0 Comments

Substituting a Type-4 Resistant Starch for Available Carbohydrate Reduces Postprandial Glucose, Insulin and Hunger:  An Acute, Randomized, Double-Blind, Controlled Study1  By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: Dietary fiber (including a wide variety of nondigestible carbohydrates) is a noted shortfall nutrient in Western diets, despite the…

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An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from the FOURIER Trial

By Kristen N Smith PhD RD LD Kevin C Maki PhD | Jan 12, 2018 | 0 Comments

An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from the FOURIER Trial (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk).1 An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from…

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Breakfast Skippers Beware: Newly Published Data on Breakfast Patterns Identifies Association with Atherosclerosis, Independent of Cardiovascular Disease Risk Factors

By Kristen N Smith PhD RDN Mary R Dicklin PhD Kevin Maki PhD | Dec 19, 2017 | 0 Comments

Breakfast Skippers Beware: Newly Published Data on Breakfast Patterns Identifies Association with Atherosclerosis, Independent of Cardiovascular Disease Risk Factors Insights from the Progression of Early Subclinical Atherosclerosis (PESA) Study By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: It is well accepted that a person’s lifestyle may impact…

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Use of Supplemental Long Chain Omega-3 Fatty Acids and Risk for Cardiac Death: An Updated Meta-Analysis and Review of Research Gaps

By Kevin Maki PhD | Oct 9, 2017 | 0 Comments

Use of Supplemental Long Chain Omega-3 Fatty Acids and Risk for Cardiac Death: An Updated Meta-Analysis and Review of Research Gaps By Orsolya M. Palacios, RD, PhD and Kevin C. Maki, PhD Randomized, controlled trials (RCTs) assessing the use of supplemental long chain omega-3 polyunsaturated fatty acids (LC-OM3), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid…

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Redefining a Healthful Diet: New Results from the Largest Observational Study Ever Conducted on Nutrition and Heart Health Challenge Current Advice

By Kevin Maki PhD | Oct 9, 2017 | 0 Comments

Redefining a Healthful Diet: New Results from the Largest Observational Study Ever Conducted on Nutrition and Heart Health Challenge Current Advice By Orsolya M. Palacios, RD, PhD and Kevin C. Maki, PhD Background Cardiovascular disease is a major cause of morbidity and mortality worldwide.  Its relationship to healthful diet and lifestyle practices has been an…

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CVD-REAL

CVD-REAL Results Suggest that Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors are, Indeed, Real

By Kevin Maki PhD | Jul 24, 2017 | 0 Comments

CVD-REAL Results Suggest that Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors are, Indeed, Real By Kevin C Maki, PhD  Background In 2015, the release of the Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial results generated significant surprise and controversy.1 The investigators randomly assigned 7,020 patients with type 2 diabetes…

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