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Substituting a Type-4 Resistant Starch for Available Carbohydrate Reduces Postprandial Glucose, Insulin and Hunger: An Acute, Randomized, Double-Blind, Controlled Study

By Kristen N Smith PhD RDN LD | Feb 15, 2018 | 0 Comments

Substituting a Type-4 Resistant Starch for Available Carbohydrate Reduces Postprandial Glucose, Insulin and Hunger:  An Acute, Randomized, Double-Blind, Controlled Study1  By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: Dietary fiber (including a wide variety of nondigestible carbohydrates) is a noted shortfall nutrient in Western diets, despite the…

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An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from the FOURIER Trial

By Kristen N Smith PhD RDN LD | Jan 12, 2018 | 0 Comments

An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from the FOURIER Trial (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk).1 An Independent Summary of Low-Density Lipoprotein Cholesterol Lowering With Evolocumab and Outcomes in Patients with Peripheral Artery Disease: Insights from…

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Breakfast Skippers Beware: Newly Published Data on Breakfast Patterns Identifies Association with Atherosclerosis, Independent of Cardiovascular Disease Risk Factors

By Kristen N Smith PhD RDN LD | Dec 19, 2017 | 0 Comments

Breakfast Skippers Beware: Newly Published Data on Breakfast Patterns Identifies Association with Atherosclerosis, Independent of Cardiovascular Disease Risk Factors Insights from the Progression of Early Subclinical Atherosclerosis (PESA) Study By Kristen N Smith, PhD, RD, LD; Mary R Dicklin, PhD; Kevin C Maki, PhD  Background: It is well accepted that a person’s lifestyle may impact…

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Use of Supplemental Long Chain Omega-3 Fatty Acids and Risk for Cardiac Death: An Updated Meta-Analysis and Review of Research Gaps

By Kevin Maki PhD | Oct 9, 2017 | 0 Comments

Use of Supplemental Long Chain Omega-3 Fatty Acids and Risk for Cardiac Death: An Updated Meta-Analysis and Review of Research Gaps By Orsolya M. Palacios, RD, PhD and Kevin C. Maki, PhD Randomized, controlled trials (RCTs) assessing the use of supplemental long chain omega-3 polyunsaturated fatty acids (LC-OM3), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid…

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Redefining a Healthful Diet: New Results from the Largest Observational Study Ever Conducted on Nutrition and Heart Health Challenge Current Advice

By Kevin Maki PhD | Oct 9, 2017 | 0 Comments

Redefining a Healthful Diet: New Results from the Largest Observational Study Ever Conducted on Nutrition and Heart Health Challenge Current Advice By Orsolya M. Palacios, RD, PhD and Kevin C. Maki, PhD Background Cardiovascular disease is a major cause of morbidity and mortality worldwide.  Its relationship to healthful diet and lifestyle practices has been an…

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CVD-REAL

CVD-REAL Results Suggest that Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors are, Indeed, Real

By Kevin Maki PhD | Jul 24, 2017 | 0 Comments

CVD-REAL Results Suggest that Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors are, Indeed, Real By Kevin C Maki, PhD  Background In 2015, the release of the Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) trial results generated significant surprise and controversy.1 The investigators randomly assigned 7,020 patients with type 2 diabetes…

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FOURIER

Putting the FOURIER Findings in Perspective

By Kevin Maki PhD | Jul 20, 2017 | 0 Comments

Putting the FOURIER Findings in Perspective By Kevin C Maki, PhD Background and Methods Earlier this year the results from the Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial were published in the New England Journal of Medicine1 in conjunction with their presentation at the American College of Cardiology…

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Changes in Diet Quality and Mortality

Changes in Diet Quality and Mortality

By Kevin Maki PhD | Jul 16, 2017 | 0 Comments

Changes in Diet Quality and Mortality By Kevin C Maki, PhD Background Sotos-Prieto and colleagues from the Departments of Nutrition and Epidemiology at Harvard University published an analysis of the relationships between changes in diet quality scores and mortality [all-cause, cardiovascular (CV), and cancer] in a recent issue of the New England Journal of Medicine.1 …

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CETP Inhibitor

Another CETP Inhibitor Fails to Show Cardiovascular Benefit, Despite Reducing LDL Cholesterol and Raising HDL Cholesterol: Implications of the ACCELERATE Trial

By Kevin Maki PhD | Jul 12, 2017 | 0 Comments

Another CETP Inhibitor Fails to Show Cardiovascular Benefit, Despite Reducing LDL Cholesterol and Raising HDL Cholesterol: Implications of the ACCELERATE Trial   By Kevin C Maki, PhD Cholesteryl ester transfer protein (CETP) is an enzyme that modulates the transfer of cholesterol esters from high-density lipoprotein (HDL) particles to apolipoprotein (apo)-B containing particles, including very-low-density lipoprotein (VLDL)…

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Health Effects of Low-Calorie Sweeteners

Debates Rage on About the Health Effects of Low-Calorie Sweeteners – Newly Published Study Shows No Effect of Sucralose on Carbohydrate Metabolism

By Kevin Maki PhD | Jul 11, 2017 | 0 Comments

Debates Rage on About the Health Effects of Low-Calorie Sweeteners – Newly Published Study Shows No Effect of Sucralose on Carbohydrate Metabolism   By Kevin C Maki, PhD A study published recently in the journal Regulatory Toxicology and Pharmacology by Grotz and colleagues investigated the effects of sucralose consumption on glucose homeostasis in healthy men and…

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